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KMID : 1377020130100020071
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Tissue Engineering and Regenerative Medicine
2013 Volume.10 No. 2 p.71 ~ p.76
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Characterization of a hybrid bone substitute composed of polylactic acid tetrapod chips and hydroxyapatite powder
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Park So-Hee
Park Sung-Hee
Park Dae-Sung
Kang Yun-Gyeong
Shin Ji-Won
Kim Hyung-Keun
Yoon Taek-Rim
Shin Jung-Woog
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Abstract
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This study evaluated a novel bone substitute composed of biodegradable polylactic acid (PLA) chips and hydroxyapatite (HA) powder. Using a microinjection molding technique, we manufactured tetrapod-shaped PLA chips, which are known to resist external loading. The roughness of the chip surface allowed for cell attachment. Also, no in vitro toxicity or reduced cellular proliferation was observed. The HA powder, made from porcine trabecular bones, had been characterized in previous studies. In the animal studies, pasted HA powder and PLA were implanted into the defective rabbit tibia. The control group was not treated with HA and PLA powder. Using X-ray analysis, micro-computed tomography, hematoxylin and eosin staining, and pathological examination for 12 weeks, we confirmed that the PLA/HA hybrid bone substitute has a potential of clinical application.
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KEYWORD
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polylactic acid, hydroxyapatite, in vitro, in vivo, tetrapod type, microinjection molding technique
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